Dr. Prafullakumar Tailor worked on HHV-6 activation in lymphoma patients towards his PhD under Dr. Robin Mukhopadhyaya from Tata Memorial Center, Bombay. With the success of Interferon therapy for CML patients at Tata Memorial Hospital he developed keen interest in Interferon Regulatory Factors (IRFs); he worked with Dr. Keiko Ozato at NICHD/NIH on regulation of type I IFN induction in dendritic cells (DCs) by viruses and Toll like receptor (TLR) ligands and innate immunityper se. Dr. Praful Tailor is recipient of Ramalingaswami Fellowship from Dept. of Biotechnology and recently a Mid-Career Scientist Award from Indian Immunology Society. Fascinated by functional specificity of diverse DC subsets, his lab at National Institute of Immunology (NII), New Delhi has contributed towards understanding the development of classical DC subtypes and focuses mainly on understanding the mechanisms of DC diversity development.
Pattern Recognition receptors (PRRs)
Host immune responses against invading pathogens depend on optimum activation of both innate and adaptive immunity. Pattern Recognition Receptors (PRRs) emerged prior to the adaptive immune responses and considered important component of innate immune response. Efficient activation of the innate immune response is pre-requisite for the specific adaptive immune responses. PRRs identifies themolecules called “Pathogen Associated Molecular Patterns” (PAMPs) recognized on the pathogens. PRRs can be broadly subdivided into different families that recognize vast varieties of PAMPs as well as Danger Associated Molecular Patterns (DAMPs) from damaged host cells. Engagement of PRRs with paired ligand stimulates signaling cascade that leads to activation of cytokine promoters. PRR signaling is intricately linked with activation of inflammasome complex triggering a pyroptosis, a form of cell death associated pro-inflammatory phenotype. We will discuss various PRR families and signal transduction events covering the diverse specificities of innate immune responses.