Dr. Jacob grew up in Southern India, where he did his primary education and moved to the United States for higher education. He received his BS degree from the University of Texas and Ph.D. from the University of Maryland School of Medicine in Baltimore. Dr. Jacob then did a 6-year post-doctoral fellowship at the Massachusetts Institute of Technology. He joined Emory University School of Medicine in Atlanta, Georgia, as a faculty, and he currently serves as a tenured Professor. His research interests focus on (a) developing novel antivirals against SARS Coronavirus-2, Dengue, and Influenzaviruses, and (b) understanding antibody responses against variant influenza viruses.
B cell responses and establishment of humoral immunity
Synopsis of lecture:
The antibody response is remarkable in its ability to respond to a seemingly endless array of antigens and to respond with enhanced vigor to pathogens encountered in the past. The lecture will cover in-depth the events that follow antigen-activation of B cells. This includes (a) differentiation into plasma cells and memory B cells, (b) class switching and affinity maturation via somatic hypermutation and antigen-driven selection, and (c) establishment of B cell memory.