Dr. Manni L Guptasarma, PhD

Dr.  Manni Luthra-Guptasarma has a Bachelors’ degree in Chemistry from Delhi University, a Masters’ degree in Biotechnology from IIT, Mumbai, a Ph.D in Molecular Biology from CCMB, Hyderabad, and postdoctoral experience in Protein Structural Biochemistry from the University of Cambridge, UK. She has worked in faculty positions at Panjab University, Chandigarh, and at the PGIMER, Chandigarh, where she is presently a Professor at the Department of Immunopathology, conducting and supervising research in several different areas of Immunology and Ophthalmology. Her areas of expertise, in addition to the above, also include molecular and cellular immunology and cell biology. Her current research interests include elucidation of mechanisms and pathways involved in immunopathological diseases such as Ankylosing Spondylitis and Rheumatoid Arthritis, as well as ocular diseases involving fibrosis in the cornea, lens and retina. She uses her background in protein chemistry, protein engineering and phage display technology to create novel enzymological and immunological protein reagents as interventional agents to explore normal and pathological states of cells and tissues.


ABSTRACT

The MHC system

The human major histocompatibility complex (MHC) isalso called the human leukocyte antigen (HLA) system.

The talk will cover the following aspects of the MHC: the historical background, molecular basis of MHC types and variants, its expression and function, structural insights, peptide binding capability, polymorphism, the inheritance of MHC, as well as the importance for species resistance to infectious disease. The talk will lastly touch upon MHC and disease association and the role played by MHC in donor-recipient matching in transplantation immunology.